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“Osteoporosis medications can increase bone formation or decrease bone break down, resulting in increased bone density, therefore, decreased risk of fracture,” said lead study author Jiannong Liu, of the Hennepin Healthcare Research Institute in Minneapolis.
“When the medication stops, bone density will decrease again,” Liu said by email.
Widespread use of bisphosphonates in the U.S. coincided with a dramatic decline in fractures from the mid-1990s to the mid-2000s. But use of these medicines has declined in recent years following reports of rare, but serious side effects including unusual fractures of the thigh bone, death of bone tissue in the jaw and esophageal cancer.
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